Midway by means of his career, Cees Dekker reinvented himself. Soon after many years of hardcore physics, he shifted his concentration to ‘nanobiology’ in the convert from the millennium. A expression he coined himself, as being a make any difference of truth.
Human Rad51 filaments on double- and single-stranded DNA: correlating frequent and irregular types with recombination purpose.
Around the exact time, the group of Paul McEuen, who was then based within the University of California, Berkeley, confirmed related final results on ropes of bundled nanotubes. Based on the wrapping angle, nanotubes can are available metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard College independently confirmed applying scanning tunnelling spectroscopy experiments.
Nanofabrication of electrodes with sub-five nm spacing for transport experiments on solitary molecules and metallic clusters
This yielded a breakthrough. Inside of only some months, we had been capable of evaluate transport by an individual one-walled carbon nanotube. According to low-temperature experiments by an excellent PhD student in my team, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation with an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being genuine quantum wires with incredibly lengthy (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Cornelis (Cees) Dekker (Haren, 7 april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en met 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We condition micro organism into varieties that deviate from their pure phenotype. Exclusively, I will display our ability to condition Stay E. coli micro organism into novel designs including rectangles, squares, triangles and circles.
Atomic power microscopy demonstrates that vaccinia topoisomerase IB generates filaments on DNA within a cooperative vogue
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1). The existing–voltage curves showed significant modulations with gate voltage, even at place temperature, which was in step with band bending in a ~0.6 eV bandgap ceesdekker semiconducting nanotube. These data also confirmed which the conductance can be modulated by six orders of magnitude by changing the gate voltage. The final results of this get the job done — a space-temperature transistor constructed from just one carbon nanotube molecule — ended up printed in Character in May 1998.
Tests pseudotopological and nontopological models for SMC-driven DNA loop extrusion versus roadblock-traversal experiments
Quite a few new phenomena have been found, and he and his investigate group established a number one placement Within this field of exploration. Dekker and his analysis team identified new physics of nanotubes in addition to explored the feasibility of molecular electronics. In 1998, they were being the 1st to construct a transistor based on one nanotube molecule.
2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; discovery of prolonged-variety conformational improvements in Mre11/DNA restore complexes; and initially force measurements over a DNA molecule in a nanopore
Strong-condition nanopores have tested to get a remarkably functional probe for solitary-molecule Investigation of DNA. I'll describe a number of our current results – specifically DNA knots – in addition to our efforts to grow the capabilities of sound-condition nanopores even even further, within the path of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.